Mendel did not use the terms gene, allele, phenotype, genotype, homozygote, and heterozygote, all of which were introduced later. Diseases such as malaria are quite common in some parts of the world, but are considered rare in the United States Other diseases such as Cancer or Alzheimer's are not rare diseases as a whole but certain forms of these disease are considered rare This list was complied primarily from data supplied by the NIH and is subject to frequent updates. The blood type of a human is determined by a gene that creates an A, B, AB or O blood type and is located in the long arm of chromosome nine. This is what the two half sisters from the question look like. That is, both loci must have at least one dominant allele to produce the phenotype. The exception being some small ones if their parents are from the same population group but still far far fewer than a full sibling. GEDmatch comparison of me and my brother full siblings You can click on the image to see the entire display at GEDmatch that this was made from. This is a list of rare diseases defined in the United States where a prevalence of less than , cases is the primary criteria. The most common allele in a population may be recessive when combined with some rare variants. Hardy-Weinberg principle The frequency of the heterozygous state which is the carrier state for a recessive trait can be estimated using the Hardy-Weinberg formula:
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